Tuesday, April 30, 2013

How does pregnancy reduce breast cancer risk?

Monday, April 29, 2013

Being pregnant while young is known to protect a women against breast cancer. But why? Research in BioMed Central's open access journal Breast Cancer Research finds that Wnt/Notch signalling ratio is decreased in the breast tissue of mice which have given birth, compared to virgin mice of the same age.

Early pregnancy is protective against breast cancer in humans and in rodents. In humans having a child before the age of 20 decreases risk of breast cancer by half. Using microarray analysis researchers from Basel discovered that genes involved in the immune system and differentiation were up-regulated after pregnancy while the activity of genes coding for growth factors was reduced.

The activity of one particular gene Wnt4 was also down-regulated after pregnancy. The protein from this gene (Wnt4) is a feminising protein - absence of this protein propels a foetus towards developing as a boy. Wnt and Notch are opposing components of a system which controls cellular fate within an organism and when the team looked at Notch they found that genes regulated by notch were up-regulated, Notch-stimulating proteins up-regulated and Notch-inhibiting proteins down-regulated.

Wnt/Notch signalling ratio was permanently altered in the basal stem/progenitor cells of mammary tissue of mice by pregnancy. Mohamed Bentires-Alj from the Friedrich Miescher Institute for Biomedical Research, who led this study explained, "The down-regulation of Wnt is the opposite of that seen in many cancers, and this tightened control of Wnt/Notch after pregnancy may be preventing the runaway growth present in cancer."

###

Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium

Fabienne Meier-Abt, Emanuela Milani, Tim Roloff, Heike Brinkhaus, Stephan Duss, Dominique S Meyer, Ina Klebba, Piotr J Balwierz, Erik van Nimwegen and Mohamed Bentires-Alj

Breast Cancer Research (in press)

BioMed Central: http://www.biomedcentral.com

Thanks to BioMed Central for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127977/How_does_pregnancy_reduce_breast_cancer_risk_

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Reconstructions: What ancient mummies have to tell us about the perils of modern life

By Matt Crenson

Web edition: April 29, 2013

Once you hit a certain age, visiting a doctor is basically a guilt trip. All that satisfying stuff you eat, drink or smoke is killing you, a white-coated overachiever tells you. You need to exercise and lose weight, or the grim reaper will be at your door long before you?re ready. And it will all be your fault.

There?s truth in that message. The primary causes of death in Western society today are cardio?vascular disease and cancer, two diseases that are very much tied up with what we put in our bodies and how we use and abuse them. If you eat a healthy diet, exercise regularly and abstain from smoking and excessive drink, your odds of living to a ripe old age do in fact increase.

But how much? Are cancer and cardiovascular disease primarily caused by the excesses of life in a modern industrial society? Or are they the inevitable end of a long and otherwise healthy life? At some level, heart disease and cancer must kill so many of us simply because in the past, plagues and saber-toothed cats beat them to it.

CT scans of ancient mummies from Egypt, Peru, Alaska and the U.S. Southwest suggest that clogged arteries have always been a fact of life, even for people who defined fast food as a swift-running ungulate. Researchers recently examined 137 mummies for evidence of calcified plaques associated with major arteries, and found that 34 percent of them probably had some atherosclerosis when they died.

Using skeletal features to estimate how old these mummies were at death, researchers showed that atherosclerosis risk increased with age. About 15 percent of those who died before age 30 had sclerotic deposits, an April 6 paper in Lancet reported, but the rate among those who died in their 40s was more than 50 percent.

The paper?s authors, an international team of pathologists and archaeologists, looked at diet and lifestyle factors that might have encouraged atherosclerosis. But there were no epidemiological smoking guns. The Egyptians ate something very close to the ?Mediterranean diet? that a recent Spanish study showed greatly benefits cardiovascular health. The Unangans of coastal Alaska ate a diet high in fish oil, which has been shown to lower cholesterol and potentially reduce cardiovascular risk. In Peru and the U.S. Southwest, people hunted, farmed and gathered a richly varied diet devoid of dairy, processed sugar and lots of other stuff that tastes really good.

The one risk factor all of these ancient people probably did face was inflammation. In the last decade or so, it has become apparent that the processes our bodies use to fight off infection and heal injury also do a lot of damage. Chronic inflammation ? even something as apparently trivial as gum disease ? has been shown to boost a person?s risk of heart attack.

In a world without antibiotics, flush toilets and Purell, the immune systems of the ancients would have been in a constant state of agitation. Other mummy studies have shown, for example, that tuberculosis was widespread in Egypt and present in the New World during ancient times.

Inflammation has been associated with cancer as well. But for some reason, researchers have found very few signs of cancer in ancient mummies. Writing in 2010 in Nature Reviews Cancer, two researchers proposed that this dearth of evidence suggests cancer may have been rare before modern times. They weren?t arguing that cancer didn?t exist at all before people started eating Cheetos and smoking Marlboros: One of the authors, retired pathologist and biologist Michael R. Zimmerman of Villanova University near Philadelphia, recently diagnosed a rectal carcinoma in an Egyptian mummy dating to the 3rd or 4th century A.D. But such diagnoses are rare. It could be that until recently people just didn?t live long enough to develop cancer very often. Or, he and A. Rosalie David of the University of Manchester in England suggested, it could be that modern life immerses us in a sea of carcinogens that ancient people never encountered.

Then again, it?s also possible that researchers just haven?t looked hard enough. When scientists from Portugal and Egypt did CT scans on three mummies housed at the National Archaeological Museum in Lisbon, they found bone lesions in and around the pelvis of a man who died 2,250 years ago that indicated prostate cancer. That discovery, described in 2011 in the International Journal of Paleopathology, was only the second oldest diagnosed case of prostate cancer: The oldest was seen in the skeleton of a Scythian king who died 2,700 years ago. Another study found 13 malignant bone tumors among 3,967 buried in Hungary between the 3rd and 16th centuries. That doesn?t sound like many, but similar cancers are no more common today.

Knowing the extent to which modern diseases are products of our environment could offer valuable clues to preventing the biggest killers of our time. But as we search for clues to our own demise in the remains of those who met theirs so many centuries ago, we should also have the wisdom to remember the message that is clearly written on every mummy?s face: Soon enough, all of us will meet their fate.

Source: http://www.sciencenews.org/view/generic/id/350014/title/What_ancient_mummies_have_to_tell_us_about_the_perils_of_modern_life

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Are private schools worth the hefty price tag?

When she was a 17-year-old high school senior applying to college, Jessica Assaf wanted more than anything to attend Brown University.

Founded in 1764, the private research university based in Providence, R.I. holds the distinction of being one of the U.S.'s oldest higher learning institutions.

Along with its Ivy League peers, it's also among the most selective colleges in the country. This year, Brown accepted just 9.2 percent of the 28,919 students that applied for the Class of 2017. When Assaf was a senior in high school back in 2007, Brown's acceptance rate stood at 13.5 percent.

Despite a strong r?sum?that included solid grades and entrance exam scores, and an enviable list of extracurricular activities, Assaf ? who attended the private, $29,800-a-year Branson School outside of San Francisco ? failed to get accepted to Brown.

At the time, she "felt like a failure," she openly admits.

Now, several years removed from that disappointment, she sees that momentary stumbling block as a precursor to everything she's been able to accomplish since.

"Not getting into Brown was the best thing that's ever happened to me," said Assaf, a vice president of sales at S.W. Basics of Brooklyn who ultimately ended up studying at NYU and has been accepted to the Harvard Business School.

The private school environment, according to Assaf, too often tended to engender in her and her classmates "an entitlement mentality."

"At NYU, in a city like New York, nothing happens for you," she said. "You have to earn every opportunity."

At Branson "you don't think you have to work hard," she added. "You think I'm here, I deserve to be here, and now everything's just going to be handed to me."

Assaf is careful to point out that she's not trying to fault her private school or in any way disparage her former classmates. Yet she also admits to being "frustrated about my high school experience, because it was so expensive and there's so much emphasis on getting into an Ivy League school."

At a time when many Americans see little choice but to tighten their belts in an economy just barely lumbering along, parents are increasingly questioning each and every purchasing decision. That includes what they're willing to pay full price for at the local supermarket, to which schools they send their children.

Read More: Jobs Picture Looks Bleak for 2013 College Grads

Some parents can afford the hefty sticker price attached to schools like Branson. However, the experience of students like Assaf, coupled with comparable data on the success rates of many gifted students who attend free public schools, has called into question the cost-benefit?or the return on investment?of a private school education overall.

Indeed, while many still believe that enrolling their child in a prestigious private school?where the cost of attendance can often exceed that seen at top colleges and universities ? is a guarantee of social status, recent evidence suggests that calculus isn't so clear cut.

Worth the Cost of Admission?
At Brooklyn's Poly Prep Country Day School, the yearly tuition is about $32,000. Students excel in the classroom, all while attempting to live up to the standard set by some of the school's notable alumni, such as Kenneth Dubertstein (class of 1961), a White House Chief of Staff to Ronald Reagan; Seth Low (1966), a former New York City Mayor; and novelist Joseph McElroy (1947).

Poly Prep's graduating seniors also routinely gain admission to some of the nation's elite colleges and universities.

"In the ever-increasing competitive world of college admissions, Poly Prep students continue to fare quite well," said Poly Prep's dean of college relations, Michael Muska, co-author of "Getting In: The Zinch Guide to College Admissions & Financial Aid in the Digital Age," on the school's site.

In an e-mail to CNBC, Muska said that "over 20 percent of last year's class attended Ivy and Little Ivy schools."

That said, Poly Prep's numbers seem to be in line with the estimated 25 percent of seniors from New York's "specialized science and math [public] high schools," like Stuyvesant High School in Manhattan ? raising the question of whether its worth it to shovel money into private schools.

According to InsideSchools.org, an independent guide to the city's public school system, the largest in the country, students that hail from New York's most rigorous and competitive schools also gain entrance to the Ivies and top private colleges at impressive rates.

Other schools, such as the Illinois Math and Science Academy in Aurora, where students are admitted in the 10th grade based on their junior high and 9th grade performance, rank among the top schools in the nation in sending students on to Ivy League schools.

Both IMSA and Stuyvesant edged out Branson in a 2007 Wall Street Journalsurvey of student admissions to a select group of elite colleges and universities. Poly Prep, however, failed to make that list. Meanwhile, the famed Dalton School in Manhattan, which cost families more than $40,000 a year, just barely made the cut.

Some experts are openly skeptical about the merits of a private school education over that of a comparably strong public school, which they argue can offer a good student the same standard of education?and chances of gaining entry to a top university ? and are free.

"I used to chuckle at parents who would send their kids off to expensive private schools rather than Oyster Bay," said Gwyeth Smith Jr, an independent college adviser and former high school counselor. "If they're bright kids, they're going to be in the same honors and AP courses that are going to be equivalent to or better than many of the private schools."

Smith said he's concerned that far too many parents and students get caught up in the "college admissions arms race."

"My last six clients have all been 9th and 10th graders," said Smith, who acknowledged that most of students he works with come from middle- to upper-income families. "That scares me."

A Competitive Advantage?

While a supporter of public schools, Smith nonetheless admits that many private schools do have some advantages, such as better student-to-counselor ratios that allow them to put a greater emphasis on the college counseling process.

Smith often advises his students to make nontraditional college choices ? such as one student he encouraged to attend USC over an Ivy League school. However, he says he's concerned with the dejection that students like Assaf experience, when the substantial investment in a high-priced secondary school education doesn't yield the return they expected.

Read More: Student Loan Borrowers Leaving Lots of Money on the Table

"Those are the kids I [worry about] more and more," he said. It's "terribly confusing" for them and their parents, "who often believe their children are the 'chosen ones.'"

David L. Marcus, who wrote a book on helping students find the "right college" couches the public-private school debate in terms of institutional shortcomings.

"Increasingly, public schools fail to prepare students for college and beyond," Marcus told CNBC in an e-mail. The 1986 Brown graduate, who has served as an admissions interviewer for the school for the past several years, added that "too many [schools] aren't emphasizing critical thinking, and they're not helping kids see the connections between science and math."

On the flip side, he says that college admissions staffs "do a fantastic job scouring public schools for poor and middle-class students who distinguish themselves," echoing Smith's sentiment that a talented student will stand out to college admissions officers more often than not.

"I look for qualities that don't show up on a high school transcript," he said. "I want someone who has an insatiable desire to learn, and who thinks critically."

So what exactly are parents getting for the hefty sums they shell out each year for a private school education?which costs a family, on average, $15,000 a year, according to the Council for American Private Education?

Part of that answer lies with the superior access and attention to detail that comes with attending private school, says Jennifer Simpson, the director of college advising at the Kent Place School, an all-girls private school in Summit, N.J.

At Kent Place, where the annual tuition is approximately $35,000?more than the cost of attending Rutgers-New Brunswick, which is about $24,000 for 2012-2013?students have access to college counselors like Simpson, who came to the school after spending several years working "on the other side of the able" in college admissions.

She admits that access is "absolutely" a key factor in many parents' decision to send their children to Kent Place. Like many private schools, Kent subsidizes the cost of attendance with generous financial aid awards.

Yet when asked about Kent Place students' admissions rates to the Ivy League and other top colleges, Simpson said she didn't feel comfortable supplying those figures. She said different people had "different interpretations" of what constitutes a top college.

Still, parents like Ginny Dameron, a school nurse in San Antonio, TX whose son attended the prestigious Phillips Exeter Academy in New Hampshire, showers praise on her son's private school experience, and the perks that came along with its price tag. Dameron's son graduated from Exeter in 2007 and from Dartmouth in 2011, and is now earning a law degree at Yale.

"I think my son went to the best school in the world," she says of Exeter, where the cost of attendance is about $45,000 a year. The school's nearly $1 billion endowment dwarfs that of many liberal arts colleges.

Read More: Why Businesses Prefer a Liberal Arts Education

Dameron says she not only received very generous financial aid from Exeter, but that the school took a genuine interest her son from the outset of the recruitment process, and continued to nurture him on through graduation.

Still, even Dameron questions whether schools like Exeter still remain the "ticket to ride" to the college or university of one's dreams they may have once been.

"I honestly don't know if that's still the case anymore," she said.

A Shifting Perspective
Admissions officers like Jarrid Whitney of the California Institute of Technology?one of the most selective universities in the country alongside peers like Stanford and MIT? downplayed any notion that students attending private schools get special consideration in the admissions process, or had any other clear advantages over their public school counterparts.

"Although private schools may, in some contexts, offer more resources in certain communities than the local public school can," Whitney, executive director of admissions and financial aid at Caltech, said in an e-mail to CNBC. "I've never felt as if attending a private school would automatically give a student any type of competitive advantage in the admissions process."

Smith, who spent close to forty years working in public schools, still believes that public schools can and should do far more to help students navigate the vexing gauntlet of college admissions. "My own children went to public schools," said Smith, whose children attended Manhasset High School on Long Island. "I believe very strongly in public education."

For her part, Assaf is enthusiastic about her current career trajectory, even if it wasn't the seamless path she anticipated as an ambitious high school senior. She doesn't mind that her life took a lengthier path to the Ivy League.

"If anything, I give all the credit to NYU," she said, noting the many interesting opportunities she's gotten due to her NYU experience.

Although Assaf said she may have had similar opportunities had she attended Brown, she wondered if she still would have believed that "everything's just going to be handed to me," as she and many of her classmates did while they attended Branson.

"I think it ultimately comes down to the individual," she said. "I think about what's gotten me to where I am now, and it has nothing to do with having gone to private school."

? 2013 CNBC LLC. All Rights Reserved

Source: http://feeds.nbcnews.com/c/35002/f/653351/s/2b451a2c/l/0L0Snbcnews0N0Cbusiness0Care0Eprivate0Eschools0Eworth0Ehefty0Eprice0Etag0E6C96410A91/story01.htm

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Monday, April 29, 2013

Drama Desk Nominations unveiled

NEW YORK (AP) ? The off-Broadway show "Giant" and the quickly shuttered Broadway musical "Hands on a Hardbody" lead the Drama Desk nomination race this season, with the British import "Matilda," the audience-friendly "The Mystery of Edwin Drood" and a revival of Stephen Sondheim's "Passion" close behind.

"Giant," based on the 1952 Edna Ferber novel of the same name, made it's off-Broadway premiere at the Public Theater this winter, and "Hands on a Hardbody," a show with songs co-written by Phish founder Trey Anastasio based on a documentary film, both earned nine nominations Monday. "Matilda," ''Passion" and "Drood" each captured seven.

Shows with six nominations are "A Christmas Story: The Musical," ''Chaplin: The Musical," ''Pippin" and "The Other Josh Cohen."

The Drama Desk, an organization of theater journalists and critics, honors both Broadway and off-Broadway productions.

The awards will be presented May 19 at The Town Hall.

___

Online: http://www.dramadeskawards.com

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-04-29-Theater-Drama%20Desk%20Nominations/id-a4f65ecbd61b4a17a7276d821ba28499

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Perry demands apology over newspaper's plant blast cartoon (CNN)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/302311437?client_source=feed&format=rss

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Pacific Rim's Latest Trailer Is Even Better Than the First

When we first saw Guillermo del Toro's Pacific Rim back in December, it was just a tease filled with robots, creatures, loud noises and explosions. And now we have a little more insight into both the mechs and creatures from a new trailer cut with scenes from Con-exclusive footage. Pacific Rim drops in theaters July 12.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/QScx2UwYA8I/pacific-rims-latest-trailer-is-even-better-than-the-fi-484612299

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Friday, April 26, 2013

Engadget Podcast 341 - 04.26.13

Engadget Podcast 341 - 04.26.13

Hold on a second. Where are you going? We know it's Friday afternoon, but what plans could be more important than your weekly slice of Engadget Podcast? Exactly. Take off your jacket, sit back down and eat it all up. You'll thank us later.

Hosts: Brian Heater, Peter Rojas, Dana Wollman

Producers: James Trew, Joe Pollicino

Hear the podcast:

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Source: http://www.engadget.com/2013/04/26/engadget-podcast-341-04-26-13/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Big K.R.I.T. Reaches Out To Spike Lee To Direct New Video, Gets A Response

FROM MTV NEWS If you caught this week's episode of "RapFix Live," you saw what may be the start of a beautiful working relationship. Big K.R.I.T. sat down with Sway to talk about some recent tweets the artist had sent out to director Spike Lee. K.R.I.T. desperately wants Lee to direct the video for his [...]

Source: http://moviesblog.mtv.com/2013/04/26/big-krit-spike-lee/

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Harvard To Close New England Primate Research Center

Humans make the results more accurate.

Consider the shoe bomber, the underwear bomber, Manson, the guy known as BTK (for "bind, torture, kill"), the Fort Hood shooter, and those guys that raped girls in Connecticut and then burned down the house with them inside. There are enough awful people that we have no shortage of humans for medical experiments.

I would have no qualms about performing the experiments. We can implant wires into their brains, give them harmful drugs, whatever... Except for the Fort Hood s

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/Us3IwAhD7Rs/story01.htm

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Yahoo! Japan Injects $20M Into Softbank Capital's Early-Stage Technology Fund '10

softbankToday SoftBank Capital, the NY-based venture arm of Japan's largest wireless provider Softbank Corp., has strengthened its ties to Japan even further, announcing that Yahoo Japan will be injecting $20 million into SoftBank's early-stage Technology Fund '10. The $20 million investment and partnership will help U.S. startups at any point in their development, from early-stage companies who need funding to more mature companies looking to expand into new markets. Yahoo Japan's investment will be an addition to the $100 million early-stage fund, which is a complement to the freshly announced PrinceVille fund.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/A5JiY01jPsc/

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Kids DIY Game Creation App TinyTap Heads To iPhone, Launches Its Own App Store

iPhone-iPad-TinyTapTinyTap, a Tel Aviv-based platform which allows children to create their own mobile games and "playable" books, is now expanding from the iPad to the iPhone, as it also launches its own social marketplace for apps. Here, users can sell their TinyTap creations to others, or just share them for free. The move comes roughly six months after the company announced its half a million dollar seed round, and detailed its plans for this "app store within an app."

Source: http://feedproxy.google.com/~r/Techcrunch/~3/m2FFwAwPLDk/

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Sorry, Readability was unable to parse this page for content.

Source: http://rss.news.yahoo.com/rss/fashion

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Algarve Holidays Make The Best Portugal Holidays!

For most holidaymakers, Portugal holidays are among the top most coveted holidays in Europe. It is not hard to understand why, as Portugal is blessed with warm favourable weather, proximity to the ocean, beautiful inland countryside, and impressive cities brimming with history and castles, pristine beaches and a warm distinctive culture. Basically, Portugal holidays can be an unforgettable experience with all the ingredients of a perfect holiday. While Lisbon, Madeira, Azores and Porto Santo are equally interesting places to visit, nothing beats the energy and vivacity of Algarve holidays! If you are planning a trip this year, make sure you plan well in advance and book beautiful Algarve villas or even a glorious Algarve Portugal beach house with a resplendent view of the Atlantic, ensuring the perfect start to a great holiday experience.

Lisbon is the capital of Portugal and a lovely city to explore, in case you plan to land at the Lisbon airport, providing the perfect start to a holiday. Located on the west coast of the country along the banks of the Tagus River, it is a historically important city, with world-renowned architecture, great shopping, dining and nightlife and several beautiful beaches along the city. A few days in Lisbon are a great introduction to all that is good about Portugal. Some popular next stops are the islands located southwest of Lisbon, in the Atlantic, comprising of Madeira, Porto Santo and some smaller ones. The climate is warm and welcoming year-round, there are gorgeous beaches, historical churches and nature reserves waiting to be explored, that are all easily accessible from the international airport in the capital city of Funchal.

The most popular destination for Portugal holidays, however, is the Algarve, the southernmost region of Portugal. Luxury Algarve villas nestling near pristine beaches, exciting nightlife, raw natural beauty and great adventure, leisure and sporting activities are some of the highlights that attract holidaymakers. If you prefer, it might be more suitable to land at the Faro airport, in the capital of the Algarve, allowing you a chance to explore the historical cities of Faro, Lagos and Silves. In fact, you could just as easily enjoy the charm of the city while relaxing in comfortable holiday rentals Faro or in an Algarve Portugal beach house, as most destinations in Algarve are not far from the beach! Living in an Algarve villa would afford you a balance of the charm and history of Portuguese culture with a blend of comforts and facilities of any modern day resort.

Porto is located in the northwest region and home to the world famous port wine. Close proximity to the Atlantic Ocean makes it ideal for sailing, fishing and other water activities. It also offers outstanding architecture, museums, shopping and restaurant experiences and many people choose Porto as the base for their Portugal holidays as it allows easy access to numerous other attractions in the region and surrounding areas.

The nine islands of Azores, approximately 900 miles from the mainland, offer beautiful beaches, breathtaking landscapes, number of water activities and caves waiting to be explored on a tranquil summer holiday. They are another reason to visit Portugal and do their part in making sure Portugal holidays stays right up there in the list of holiday destinations for holidaymakers...

About the Author:
The choice of Holiday Rentals Algarve includes small hotels, large hotels, sports complex accommodation and all manner of villas in the Algarve.

Source: http://www.articlesnatch.com/Article/Algarve-Holidays-Make-The-Best-Portugal-Holidays-/4569491

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Reporter at Murdoch's The Sun charged over bribery

LONDON (AP) ? A senior reporter at Rupert Murdoch's The Sun newspaper is being charged with conspiring to pay 23,000 pounds (roughly $35,000) in bribes in return for tips about the royal family, prosecutors said Wednesday.

The Sun's Chief Royal Correspondent Duncan Larcombe is alleged to have conspired with employees of Sandhurst ? Britain's prestigious military academy ? to secure royal gossip. Although the statement does not go into detail, Princes William and Harry both trained at Sandhurst several years ago and the younger royals have long made tempting targets for scandal-hungry tabloids.

Larcombe joins a growing list of Sun staff who have found themselves in the dock over the paper's shaky ethics.

The paper's executive editor, Fergus Shanahan, faces a bribery-related charge. The Sun's deputy editor, Geoff Webster, The Sun's defense editor, Virginia Wheeler, and The Sun's former chief reporter, John Kay, also face charges. So too does The Sun's former editor, Rebekah Brooks.

The Sun's crime editor, Mike Sullivan, was arrested last year but recently learned he would not face charges.

The wave of legal action is linked to the phone hacking scandal which exploded at Rupert Murdoch's News Corp. empire in 2011. The scandal shook Britain's establishment with revelations of industrial-scale espionage, phone hacking, bribery, blackmail, and influence peddling. Scores of journalists, police officials, and executives have been arrested or lost their jobs.

Source: http://news.yahoo.com/reporter-murdochs-sun-charged-over-bribery-123128424--finance.html

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Thursday, April 25, 2013

Psychopaths are not neurally equipped to have concern for others

Psychopaths are not neurally equipped to have concern for others [ Back to EurekAlert! ] Public release date: 24-Apr-2013
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Contact: William Harms
w-harms@uchicago.edu
773-702-8356
University of Chicago

Prisoners who are psychopaths lack the basic neurophysiological "hardwiring" that enables them to care for others, according to a new study by neuroscientists at the University of Chicago and the University of New Mexico.

"A marked lack of empathy is a hallmark characteristic of individuals with psychopathy," said the lead author of the study, Jean Decety, the Irving B. Harris Professor in Psychology and Psychiatry at UChicago. Psychopathy affects approximately 1 percent of the United States general population and 20 percent to 30 percent of the male and female U.S. prison population. Relative to non-psychopathic criminals, psychopaths are responsible for a disproportionate amount of repetitive crime and violence in society.

"This is the first time that neural processes associated with empathic processing have been directly examined in individuals with psychopathy, especially in response to the perception of other people in pain or distress," he added.

The results of the study, which could help clinical psychologists design better treatment programs for psychopaths, are published in the article, "Brain Responses to Empathy-Eliciting Scenarios Involving Pain in Incarcerated Individuals with Psychopathy," which appears online April 24 in the journal JAMA Psychiatry.

Joining Decety in the study were Laurie Skelly, a graduate student at UChicago; and Kent Kiehl, professor of psychology at the University of New Mexico.

For the study, the research team tested 80 prisoners between ages 18 and 50 at a correctional facility. The men volunteered for the test and were tested for levels of psychopathy using standard measures.

They were then studied with functional MRI technology, to determine their responses to a series of scenarios depicting people being intentionally hurt. They were also tested on their responses to seeing short videos of facial expressions showing pain.

The participants in the high psychopathy group exhibited significantly less activation in the ventromedial prefrontal cortex, lateral orbitofrontal cortex, amygdala and periaqueductal gray parts of the brain, but more activity in the striatum and the insula when compared to control participants, the study found.

The high response in the insula in psychopaths was an unexpected finding, as this region is critically involved in emotion and somatic resonance. Conversely, the diminished response in the ventromedial prefrontal cortex and amygdala is consistent with the affective neuroscience literature on psychopathy. This latter region is important for monitoring ongoing behavior, estimating consequences and incorporating emotional learning into moral decision-making, and plays a fundamental role in empathic concern and valuing the well-being of others.

"The neural response to distress of others such as pain is thought to reflect an aversive response in the observer that may act as a trigger to inhibit aggression or prompt motivation to help," the authors write in the paper.

"Hence, examining the neural response of individuals with psychopathy as they view others being harmed or expressing pain is an effective probe into the neural processes underlying affective and empathy deficits in psychopathy," the authors wrote.

Decety is one of the world's leading experts on the biological underpinnings of empathy. His work also focuses on the development of empathy and morality in children.

The study with prisoners was supported with a $1.6 million grant from the National Institute of Mental Health.

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Psychopaths are not neurally equipped to have concern for others [ Back to EurekAlert! ] Public release date: 24-Apr-2013
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Contact: William Harms
w-harms@uchicago.edu
773-702-8356
University of Chicago

Prisoners who are psychopaths lack the basic neurophysiological "hardwiring" that enables them to care for others, according to a new study by neuroscientists at the University of Chicago and the University of New Mexico.

"A marked lack of empathy is a hallmark characteristic of individuals with psychopathy," said the lead author of the study, Jean Decety, the Irving B. Harris Professor in Psychology and Psychiatry at UChicago. Psychopathy affects approximately 1 percent of the United States general population and 20 percent to 30 percent of the male and female U.S. prison population. Relative to non-psychopathic criminals, psychopaths are responsible for a disproportionate amount of repetitive crime and violence in society.

"This is the first time that neural processes associated with empathic processing have been directly examined in individuals with psychopathy, especially in response to the perception of other people in pain or distress," he added.

The results of the study, which could help clinical psychologists design better treatment programs for psychopaths, are published in the article, "Brain Responses to Empathy-Eliciting Scenarios Involving Pain in Incarcerated Individuals with Psychopathy," which appears online April 24 in the journal JAMA Psychiatry.

Joining Decety in the study were Laurie Skelly, a graduate student at UChicago; and Kent Kiehl, professor of psychology at the University of New Mexico.

For the study, the research team tested 80 prisoners between ages 18 and 50 at a correctional facility. The men volunteered for the test and were tested for levels of psychopathy using standard measures.

They were then studied with functional MRI technology, to determine their responses to a series of scenarios depicting people being intentionally hurt. They were also tested on their responses to seeing short videos of facial expressions showing pain.

The participants in the high psychopathy group exhibited significantly less activation in the ventromedial prefrontal cortex, lateral orbitofrontal cortex, amygdala and periaqueductal gray parts of the brain, but more activity in the striatum and the insula when compared to control participants, the study found.

The high response in the insula in psychopaths was an unexpected finding, as this region is critically involved in emotion and somatic resonance. Conversely, the diminished response in the ventromedial prefrontal cortex and amygdala is consistent with the affective neuroscience literature on psychopathy. This latter region is important for monitoring ongoing behavior, estimating consequences and incorporating emotional learning into moral decision-making, and plays a fundamental role in empathic concern and valuing the well-being of others.

"The neural response to distress of others such as pain is thought to reflect an aversive response in the observer that may act as a trigger to inhibit aggression or prompt motivation to help," the authors write in the paper.

"Hence, examining the neural response of individuals with psychopathy as they view others being harmed or expressing pain is an effective probe into the neural processes underlying affective and empathy deficits in psychopathy," the authors wrote.

Decety is one of the world's leading experts on the biological underpinnings of empathy. His work also focuses on the development of empathy and morality in children.

The study with prisoners was supported with a $1.6 million grant from the National Institute of Mental Health.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/uoc-pan042313.php

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Wednesday, April 24, 2013

A look at immigrant patients deported by hospitals

(AP) ? Over the last five years, American hospitals have sent at least 600 immigrants who were in the U.S. illegally back to their home countries to avoid paying for long-term care after serious illness or injury.

The Center for Social Justice at Seton Hall University has documented "medical repatriation" cases in 15 states involving patients from El Salvador, Guatemala, Honduras, Lithuania, Mexico, the Philippines and South Korea.

Here's a look at some of the most dramatic examples from a report issued in December:

___

Quelino Ojeda Jimenez was working atop a building at Chicago's Midway Airport in 2010 when he fell, suffering injuries that left him nearly quadriplegic and reliant on a ventilator.

Advocate Christ Medical Center cared for Jimenez for four months, absorbing more than $650,000 in costs, according to a 2011 Chicago Tribune story.

Three days before Christmas that year, the hospital put him aboard a medical flight and sent him to Mexico, even though his family protested. Crying and unable to speak, Jimenez could do nothing to prevent his removal.

The receiving hospital in Mexico lacked rehabilitation services and could not afford new filters for his ventilator. After suffering two heart attacks and a septic infection, Jimenez died on Jan. 2, 2012.

___

Luis Alberto Jimenez was working as a landscaper in Florida when the car he was in was struck by a drunk driver in February 2000.

Jimenez, then 35, suffered brain damage and other injuries and was treated at Martin Memorial Medical Center in Stuart, Fla., until June, when he was transferred to a nursing home.

The following January, he was readmitted to the hospital with an infection that doctors feared could be fatal. He stayed at the hospital for a year because no other long-term care provider would take him.

The hospital eventually filed a lawsuit in state court seeking permission to transport him to a hospital in his native Guatemala. A judge approved the flight in June 2003, and Jimenez was flown to Guatemala before the court could rule on an appeal filed by his legal guardian.

In mid-2004, the Florida District Court of Appeals overturned the lower court's order, declaring that state courts do not have the authority to permit deportations, which are regulated by federal immigration law. But by then Jimenez had been returned home, bedridden and suffering from seizures, to live with his elderly mother in a remote area of Guatemala.

___

Barbara Latasiewicz was working as a housekeeper in the Chicago area in 2009 when she had a stroke while scrubbing a bathtub. The Polish woman was paralyzed on her left side and needed around-the-clock care.

Adventist La Grange Memorial Hospital tried to find her long-term care, but 30 facilities refused to take her because she was undocumented. Latasiewicz had overstayed a temporary visa after arriving in the U.S. in 1990.

The hospital allowed her to stay without insurance or any other way to pay for 2? years at a cost of more than $1.4 million.

In early 2012, arrangements were made to transfer her to a stroke-specialty unit in Poland. She refused to consent to the transfer, which would permanently separate her from her son and grandchildren. The hospital obtained a judge's order allowing her transfer to Poland.

A March 1 story in the Chicago Tribune says the 60-year-old woman cried while sitting in the airport awaiting a flight out, knowing she would probably never return to the U.S., which had been her home for more than 20 years.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-04-23-US-Hospital-Deportations-Immigrant-Stories/id-e1f4bebc9ddc432f9dbc7b4032c73ddc

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Engadget Eurocast 024 - 04.24.13

Engadget Eurocast 024 - 04.24.13

Take a look around you, what do you see? Walls? People? An office? Take it all in, suck it all up. Why? Because today all that changes forever. Jamie's revelation that he's a University Challenge nut flips everything we know on its head. Also, Mat drops "convincement" like it wasn't even a thing. This madness is the Eurocast.

Hosts: Dan Cooper, Mat Smith, Jamie Rigg

Producer: James Trew

Hear the Podcast

Filed under:

Comments

Source: http://www.engadget.com/2013/04/24/engadget-eurocast-024-04-24-13/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Battling with bugs to prevent antibiotic resistance

Apr. 23, 2013 ? New scientific research published today in the journal PLoS Biology shows that bacteria can evolve resistance more quickly when stronger antibiotics are used.

Researchers from the University of Exeter and Kiel University in Germany treated E. coli with different combinations of antibiotics in laboratory experiments.

Unexpectedly they found that the rate of evolution of antibiotic resistance speeds up when potent treatments are given because resistant bacterial cells flourish most during the most aggressive therapies.

This happens because too potent a treatment eliminates the non-resistant cells, creating a lack of competition that allows resistant bacteria to multiply quickly. Those cells go on to create copies of resistance genes that help them rapidly reduce the effectiveness of the drugs. In tests this effect could even cause E.coli to grow fastest in the most aggressive antibiotic treatments.

In addition to evolution experiments, the results of this Engineering and Physical Sciences Research Council (EPSRC) and Medical Research Council (MRC) funded research were confirmed using mathematical models and whole-genome sequencing of resistant and non-resistant E. coli.

Professor Robert Beardmore, EPSRC Research Fellow from the University of Exeter said: "We were surprised by how quickly the bacteria evolved resistance. We nearly stopped the experiments because we didn't think some of the treatments should be losing potency that fast, sometimes within a day. But we now know that the bacteria remaining after the initial treatment have duplicated specific areas of their genome containing large numbers of resistance genes. These gene copies appear more quickly when the antibiotics are combined, resulting in the rapid evolution of very resistant bacteria.

"Designing new treatments to prevent antibiotic resistance is not easy, as this research shows, and governments may need to increase their funding for antibiotics research if scientists are to be able to keep pace with the rapid evolution of bacterial pathogens that cause disease."

Dr Rafael Pena-Miller from Biosciences at the University of Exeter said: "The evidence that combining antibiotics to make a more potent therapy can lead to the creation of more copies of the genes the bacteria needs to be resistant is of real concern."

Professor Hinrich Schulenberg from Kiel University in Germany said: "The interesting thing is that the bacteria don't just make copies of the genes they need. Just in case, they copy other genes as well, increasing resistance to antibiotics the cells weren't even treated with."

About 440 000 new cases of drug-resistant tuberculosis emerge annually, causing around 150 000 deaths. Statistics like this recently lead the Department of Health to state that antibiotic resistance poses one of the greatest threats to human health.

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The above story is reprinted from materials provided by University of Exeter, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/zprA_T5Qf9w/130423172704.htm

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Event: Does Your Marketing Suck? - Dana Wilde

desiree-marketing

2013 is going to be an exciting year for the small business, direct sales and network marketing industry. More and more people are taking their business from hobby to profit. Even if you?ve been established, growing isn?t always easy and many entrepreneurs begin to feel stuck, or stagnant in their business.

Join Desiree Wolfe, CEO of Desiree Marketing and VP of Marketing at The Mind Aware, along side host, Dana Wilde of The Mind Aware on this FREE webinar that every small business owner will want to attend!

Thursday, April 25, 2013

9am Pacific Time / 10am Mountain / 11am Central / 12pm Eastern Time

RSVP for this special event designed to give you all the empowerment you need to take your business to the next level.

https://br122.infusionsoft.com/app/page/grow2013

This 60 minute class will teach you:

  • How to effectively manage your time
  • How to control your sales.
  • How to create successful customer service habits.
  • How to overcome the biggest challenges you face with your business.

?This free webinar will be recorded but you must register to receive the replay information.

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Source: http://danawilde.com/event-does-your-marketing-suck.html

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Hunter Hayes, Stevie Wonder Have 'Emotional' Reunion On 'Dancing With The Stars'

Be sure to catch Hunter's live Twitter Q&A with @CMT April 24 at 2 p.m. ET!
By Jocelyn Vena

Source: http://www.mtv.com/news/articles/1706171/hunter-hayes-stevie-wonder-dancing-with-the-stars.jhtml

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Infinity Cell Lets You Charge Your iPhone Simply By Shaking It

Infinity_Cell_smartphone_Kinetic_Charger_1The Infinity Cell is a kinetic charger for the iPhone that uses your body's movement to generate electricity. The current prototype for the Infinity Cell is a crude 3D printed rectangle, roughly the size of a pack of cigarettes, linked up to the iPhone with a cable. The plan is to create a more streamlined version during the product's Kickstarter campaign.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/hPfrNCPcDNo/

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Playing With My Food!: HealthFare Restaurant Review

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Last week I was invited in as a 'food blogger' to do a tour and menu tasting of a new local healthy fast food restaurant, HealthFare. I arrived not knowing what to expect...would they be nice? ?What if they noticed that I didn't have a fancy food blogger camera, business cards for my blog, and an extensive knowledge of...well, food? ?What if I didn't like the food or the restaurant - would I have to fake it? ?Would they be able to tell right away that I've never done this type of thing before? I needn't have worried, because the mother-son owner team of Jenni and Shaun Saini were completely welcoming, the restaurant was beautiful,?my point and shoot camera did the trick,?and most importantly...the food was fan-freaking-tastic!

It's guilt-free eating at its best, and here's why...

HealthFare offers you four things that your regular fast food restaurant never tends to:

1) It's Healthy! ?

Yes, I know, that was kind of an obvious one since the word Health is actually in the name of the restaurant, and the slogan is 'making healthy delicious.' ?But it is?rare to find an entirely healthy menu at a fast food restaurant, so I found this feature to be incredibly impressive. ?Everything is pre-portioned out so that there is precisely (and I do mean precisely) the exact same amount of ingredients going into each and every menu item each and every time. ?The reason that they are so strict on this is because the menu is created by a team of Registered Dieticians, and they never want to stray from having all of the nutritional facts be completely and 100% accurate with every serving. ?The calories are listed right on the menu, and all of the additional nutritional information is readily available.

You know a place is healthy when they don't even offer any Pepsi or Coke products in-store. ?There is actually no pop available at all, and instead they stock beverages like BLK fulvic-enhanced mineral water, coconut water, and Steaz iced tea. ?There's no super-sizing at a place like this, unless you count this gigantic lemon water pitcher. ?


Ok, and guys? ?They have these green smoothies there that have spinach in them, and I drank one, and and I liked it. ?I'm a total first-timer in the green smoothie department, and like seriously, I don't understand how that can even be good, but it was better than good. ?It was delicious in fact, all blended up with tropical fruit other awesome healthy things. I seriously think I drank it in like 28 seconds and didn't pay attention to anything or anyone else while it was happening, because that green smoothie became my world for half a minute. ?Somehow I know that if I tried to make this at home it would be completely awful, but HealthFare made a green smoothie into something that I have been craving since my visit.

2) It's Fresh!

I was taken on a little tour of the restaurant and got to see the back of the house. ?While I was there, one of the cooks was slicing up fresh boneless, skinless chicken breast for later use in a rice bowl.

When was the last time that a fast food restaurant chain used fresh chicken breast in their menu? ?Probably never. ?But this place does. ?In fact, nothing is brought in pre-made. ?Everything, right down to their delicious sauces and salad dressings, is made in-house so that it's as fresh as can be and without any unnecessary preservatives, additional sodium, or other nasty chemicals.
All of the baked goods are made fresh daily too. ?All meals are made to order while you are there, with the average wait time at under five minutes from the time you order to the time that you're chowing down. ?It gives the term 'eat fresh' a whole new fast food meaning.

3) It's Earth-Conscious!

HealthFare is?a bright, beautiful, inviting, 'eco-chic' restaurant. ?Even the furniture is designed with sustainability and environmental responsibility top of mind. ?The chairs are made from BMW-designed recycled materials, the flooring is made from natural and renewable supplies, and the ceiling is made from recycled Japanese kirei board.

They use biodegradable to-go containers rather than styrofoam so that your take-out packaging doesn't end up in a landfill.
They even pour?Kicking Horse Coffee?(reason alone for a few people that I know to become regular patrons), who just like HealthFare are also focussed on environmental sustainability and community.

4) It's suitable for vegans, vegetarians,?glutards...and kids! ?

I have to tell you that since going gluten-free in July 2012, I haven't been eating much fast food. ?It's not that I was ever really one to frequent McDonalds or Taco Bell, but it was nice to have options if I ever was on the road and needed something quickly. ?But since the big diet change in July, I haven't been able to find a fast food restaurant that I can go to with confidence and know that what I am eating is gluten free. ?With HealthFare, a lot of the menu is gluten free, without the requirement for me to have to make modifications to my order. ?They have symbols beside each menu item to indicate if it is vegan, vegetarian, or gluten free, so that you're able to easily identify what items are appropriate for whatever special dietary requirements that you may have. ?I actually had options to choose from on the menu at HealthFare, which is unusual for someone on a gluten free diet. ?It was kind of like a gluten free Disneyland, especially because as I mentioned I got to do a menu tasting, and boy did I ever tuck it back. ?But everything was better than the thing I had just tried, and I just had to keep eating and eating. ?From the savoury rice bowls, to the wholesome salads, to the artisan sandwiches, to the healthy soups, and finally to the frozen yogurt, this place has something for everyone.

My personal favourite is something called The Bakker Bowl, named after HealthFare's creator, Mark Bakker. ?The Bakker is sort of a cross between a rice bowl and a salad, served cold and overflowing with roasted marinated chicken breast, whole-grain brown rice, cherry tomatoes, feta, and ranch dressing.
They even offer a kids menu, with healthy choices under 500 calories like Multigrain Grilled Cheese or Polka Dot Pizza.

I was turned on to something new while I was there, which is the Vega line of vegan protein products. ?Healthfare offers this brand at the suggested market price, rather than marking it up in a crazy way like some retailers do.


HealthFare is totally responsive to the changing needs of their customers as well as new trends. ?For instance, they noticed that customers were coming in and requesting almond milk, but it wasn't something they carried. ?The next week they started stocking it in their fridge. ?They were also noticing that people who eat tofu prefer for it to be certified organic tofu, which the brand that they were carrying was not. ?Shortly thereafter, they made the switch to an organic tofu to please their customers. ?This is a restaurant that is not afraid to try new things and to break the mould to please the ever-changing needs of their more health-conscious customers.

The restaurant concept began in Alberta, where there are currently two locations. ?The new B.C. location that I visited is at 7366 Market Crossing, in Burnaby, which is in the new-ish Market Crossing shopping centre at Byrne Road and Marine Way. ?From the Healthfare Facebook page I've learned that ?there are currently franchise opportunities in Port Coquitlam, downtown Vancouver, and Surrey. ?There are also new stores popping up soon in the lower mainland, with locations being announced imminently.

Hopefully restaurants like Healthfare are the way of the future, as they bridge between food being convenient and quick, while still allowing you to make healthy lifestyle choices. ?I wish them all of the success in their quest to serve healthy, delicious food fast and in a sustainable way, and look forward to seeing more Healthfare locations sprout up in the lower mainland soon.

One word of warning...do not start yourself on eating the house-made seasoned almonds that they sell by the small container-ful, unless you never ever want to stop thinking about them again. ?They are highly addictive in the way that salty-sweet things always are to me. ?I now think about them often and with much fondness.


Thank you for the invitation HealthFare!

You can visit HealthFare online at www.healthfare.ca.
Check out HealthFare's Facebook page by searching HealthFare - Making Healthy Delicious
Follow HealthFare on Twitter at?@HealthFare

Source: http://www.playingwithmyfood.net/2013/04/healthfare-restaurant-review.html

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GWH News and Notes: Resistance Pro Wrestling Television Episode 9

Sorry, Readability was unable to parse this page for content.

Source: http://www.gwhnews.com/2013/04/resistance-pro-wrestling-television.html

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Tuesday, April 23, 2013

Chaz Bono shows off 60-pound weight loss

Getty Images / FilmMagic file

Chaz Bono is shown at left at the Outfest opening night gala in Los Angeles on July 9, 2009, and on Saturday at the 24th Annual GLAAD Media Awards in Los Angeles.

By Kurt Schlosser, TODAY

Chaz Bono got motivated and went "Dancing With the Stars" a couple years ago, and now the reality star is taking on what he eats and showing great results -- he's lost 60 pounds.

Bono tweeted earlier this month that he hit the mark and tells People magazine in a new story that he's "still slowly losing" weight.

"I've just changed the way I eat," Bono told People. "Diets don't work. You just have to change what you eat, and I have." It was an assertion he also tweeted about on April 8, listing some of the food and exercise that's working for him.

In November, Bono detailed how he was setting out to lose weight with an appearance on "The Doctors." At 5 feet, 5 inches and 250 pounds, Bono, 44, said he had struggled with weight since his mid-20s. He was advised by experts on the show to lose 50 to 80 pounds.

Bono (formerly Chastity) documented his female-to-male gender transition in the 2011 film "Becoming Chaz."

Source: http://todayentertainment.today.com/_news/2013/04/22/17864336-chaz-bono-shows-off-60-pound-weight-loss?lite

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Sunday, April 21, 2013

MOTU Digital Performer 8 (for Mac)


If there's a single digital audio workstation package that's more closely associated with the Mac than any other, it's MOTU's Digital Performer. In the digital audio-enabled version's eighth iteration ($499 list), MOTU's flagship DAW remains a premier tool for MIDI composition and film scoring, and it contains enough audio-editing tools to serve as a solid all-around multitrack recorder. When MOTU introduced version 8 last October, the company announced a PC version for the first time, although it's still not available yet. On the Mac, at least, I've been using Digital Performer on and off for over 20 years, with my first experience being with the MIDI-only Performer in a college music lab on a Mac IIsi; this latest version is a true pleasure to work with.

System Requirements and Plug-in Formats
For this review, I tested Digital Performer 8 on two machines: a quad-core Mac Pro (2009) running OS X Lion, and a quad-core MacBook Pro 15-inch (2012) running OS X Mountain Lion. Digital Performer installs very quickly, as it takes up just 1.7GB of hard disk space. Part of the reason for that is that the program still lacks key virtual instrument plug-ins (more on that later).

The big news is that Digital Performer is now 64-bit for the first time, which means it can address more than 4GB of memory?a huge boon for anyone working with large virtual instrument samples. As long as your third-party plug-ins are also 64-bit, you can get a lot more out of the program than you could before. The UI is also 100 percent Cocoa this time around; performance seemed snappy on both test machines.

Fortunately, there's no hardware-based copy protection. On the software side, MOTU gives you two activations, so you can use the program on, say, a desktop and a laptop. Install and activate DP8 on a third machine, and it doesn't fight you; it just deactivates the first one. This is far preferable to Steinberg's copy protection scheme for Cubase 7, which uses a proprietary eLicenser dongle, or Avid's for Pro Tools 10, which relies on the more common but still frustrating iLok key?both of which take up one of the two precious USB ports on all Mac laptops. Apple Logic Pro and the PC-based Cakewalk SONAR still lead in that they don't require copy protection at all. But I personally have no problem with software activations as long as they work reliably and are easy to perform.

User Interface and Recording
If you've used Digital Performer before, you'll find the main user interface environment instantly familiar. The consolidated interface lets you display multiple views simultaneously. I found that I liked working with the Tracks view to the top left, audio or MIDI editing in the bottom left, and the mixing board to the right, but you can create just about any setup using the horizontal and vertical drawbars in each window.

The UI works particularly well on lower-resolution MacBooks and MacBook Pros. I could fit a ton of data on-screen, including 24 track lanes, a score or piano roll editor, and eight mixer channels off to the right. New themes give you an additional 15 options for the look of the program, but it's not just about color?the look of the sliders, pan pots, and meters also changes with each theme.

For recording audio, a new Punch Guard mode is one of those forehead-slapping obvious features that should have been there from the beginning. It always ensures you don't lose the front or tail of a good take, because the feature is constantly capturing extra time before and after your punch points. One of my favorite features is DP's free companion iPhone app, which I tested on an iPhone 5. The app gave me instantaneous, reliable control of the transport, take management, and even mixing board faders, which freed me up to sit in front of actual instruments instead of the computer while recording.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/vTZH0huZiFs/0,2817,2417727,00.asp

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