Sunday, March 31, 2013

Email Marketing As Business Growth Partner

In the modern business world, new business competitors are emerging every day. Every business owner wants to reach the maximum number of potential clients and customers. The most noteworthy thing for increasing the customer base is to build cordial and personalized relationships with our customers.

Internet marketing provides us with the ultimate platform to take our business to reach new heights. It helps a lot by making alignment in the way that customers make purchases and thus influence their decisions. As we all know the maximum number of customers research on websites and social media sites before making their purchase. It provides them a platform to perform product comparisons on the basis of quality and prices. It plays a pivotal role in making excellent relations with customers.

Email marketing services have created a revolutionized growth in the whole business world. Businesses are achieving excellent benefits through this service.

The foremost thing is that the marketing services through emails have to be creative and resourceful to guarantee overall business growth. There are many email marketing companies making the industry stiff with competition. However, these all marketing services aimed at the guaranteed success of our business and follow the basic marketing principles. At the initial stage, we should set small and realistic goals. This finalises our business success in the market. Our business will surely achieve high growth because of these marketing activities, but there always be effective and cost-efficient ways to market services and products.

The email marketing services are far better than web-based email programs because it provides us with bulk of useful services such as automatic list generation and management, email marketing statistics, and scheduled emailing.

There are various companies available that helps your business growth through website development and overall marketing. They also help in putting your entire traditional business online. They provide assistance in transition and adoption of modern business practices making use of the web technology power. They also leads to the development of create intuitive designs and high-end cloud applications for web, mobile mediums, print, multimedia, social media and E-commerce.

Email marketing is basically concerned for marketing our commercial messages around a group of people via emails. Every email is sent to each potential or current customer so as to enhance the business using email marketing. It also involves the use of email to send ads, solicit sales, request business, or donations, and is meant for building the trust, loyalty and brand awareness. Email marketing can be done for either current customer database or cold lists. It not only enhances the relationship of a merchant with its previous and current customers but also proves vital in convincing current customers. It forces them to purchase new things thus also acquiring more and more customers. This really proves very useful in encouraging customer trust and loyalty, thus benefitting our business.

So be ready to experience an easy and effective way to connect with millions of your customers. Let them also to share and their views regarding your product over their huge networks. The real Growth starts now.

Source: http://www.informationbible.com/article-email-marketing-as-business-growth-partner-296779.html

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N. Ireland struggles to confront Catholic Church?s enslavement of 1000s of women (Americablog)

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This Week's Top Comedy Video: Chris Brown's Publicist

The life of a hotshot Hollywood publicist isn't one you'd envy under the best of circumstances. But the guy who has to cover Chris Brown's back? That's some kind of martyr. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/AoeWDc1xy7I/this-weeks-top-comedy-video-chris-browns-publicist

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Saturday, March 30, 2013

Christians Worldwide Prepare for Easter (Voice Of America)

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Quick View (for Android)


Quick View (free) for Andorid is the mobile companion to DigitalQuick, a service that allows you to easily encrypt files on your computer and on the file-syncing service Dropbox. DigitalQuick also allows you to control what other people can do with your secure documents, such as edit, copy, and print.

Though still in beta, DigitalQuick and Quick View offer a solution for individuals and businesses who want to take advantage of Dropbox's low cost and utility without compromising security. However, Digital Quick is quirky and the mobile app is no different. In my testing, Quick View lived up to its name: With it, you can quickly view secure files on the go?and little else.

Finding Files
Getting files into Digital Quick is a bit of a Byzantine process, requiring you to encrypt files on your computer and then move them on to your Android device via USB. Then, you fire up a file manager on your Android device (I use the Astro File Manager) and move the files into the My Documents directory inside the Quick View folder.

Did you have Quick View running while you did this? Well, you'll have to wait a full ten minutes before the app will sync with the DigitalQuick servers and update the permissions for the files you've moved. Until then, you'll see confusing error messages. There's no way to force the app to refresh, so you'll have restart the app, or move files into the Quick View directory before launching the app.

The Fassoo.com team has told me that future versions will include real-time permissions updating.

DigitalQuick's selling point is its support for Dropbox, and accessing your secure files from that service is straightforward with Quick View. Just tap the large Dropbox icon on the app's homescreen, tap allow on the next screen, and your DigitalQuick files (along with everything else in your Dropbox account) is available.

The process for linking Dropbox to DigitalQuick and adding encrypted files is covered in our review of the Web service.

Working With Quick View
Once you have access to your files, Quick View lets you view the contents without decrypting the files. Unfortunately, the built-in document viewer will not let you copy, edit, save, or really do anything with your documents.

You can decrypt files, removing all permissions and encryption, to share with users who aren't DigitalQuick users. Doing so, of course, defeats the purpose of using a document security system. You can also view the permissions assigned to a document, such as limitations on editing and printing. Unfortunately, you cannot change the permissions from the app?to do so, you'll have to login to the DigitalQuick website.

Quick View lets you share DigitalQuick documents via email, which is useful if your files are stored locally. Dropbox has more robust sharing options, though, which don't appear to affect the encryption or permissions of DigitalQuick documents. So you may be better off just sharing your documents through Dropbox directly.

Prior to publishing this review, DigitalQuick's developers informed us that an update allows users to import files directly from Dropbox without decrypting them and for users to access their local encrypted files without an Internet connection. These are welcome additions, but did not affect the score of the review.

Not for the Faint of Heart
If you're an avid DigitalQuick user already familiar with its quirks, using Quick View is a no brainer?despite all its drawbacks. If you're not a Digital Quick user, the app serves no purpose.

Because the service is still in beta, I don't want to be overly harsh, but users should be aware that Quick View is far from a finished product. The utility of being able to view and decrypt files is overshadowed by the difficulty in opening them, and the app lacks critical features like a built-in file manager and document editor. Though the app looks well-made it badly needs an improved user interface as the current version is difficult to use and completely un-intuitive. The included documentation did little to relieve my confusion.

The time has come for a service like DigitalQuick, but it and Quick View need to mature before they'll be ready to fill that niche.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/fFoNMA6KU00/0,2817,2417151,00.asp

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James Holmes plea rejected: Are prosecutors prepping for death penalty?

James Holmes would have pleaded guilty had he been spared death, but the proposal was rejected by prosecutors ? another sign they might be preparing to seek the death penalty.

By Mark Guarino,?Staff writer / March 29, 2013

James Holmes, Aurora theater shooting suspect, sits in the courtroom during his arraignment in Centennial, Colo., earlier this month.

RJ Sangosti/Denver Post/AP/File

Enlarge

Prosecutors are rejecting a plea agreement proposed by defense attorneys for James Holmes, the primary suspect in the mass shooting at a movie theater in Aurora, Colo., that killed 12 and injured 70 last July. The agreement proposes a guilty plea if Mr. Holmes does not receive the death penalty.

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Without a guilty plea from Holmes, his mental health would likely be the big question mark in a potential trial. Indeed, prosecutors said in court documents Thursday that the plea they rejected was ?a calculated attempt? by the defense to convince the public that the criminal insanity defense has merit.

At an August hearing immediately following the shooting, Holmes's attorneys told a judge that his client was mentally ill and time was needed to assess the extent and nature of his illness. There were also references to a notebook the former University of Colorado graduate student shared with a school psychiatrist, in which he portrayed violent acts.

Prosecutors have long argued the notebook should be made trial evidence, but the defense says it is protected by physician-patient privilege. In a court document filed Thursday in Denver, prosecutors are accusing the defense of refusing to cooperate with document requests.

?The defendant knows that he is guilty, the defense attorneys know that he is guilty, and that both of them know that he was not criminally insane? is the inevitable conclusion of his crimes, they said.

The insanity defense will make the trial difficult for the prosecution because, in contrast to the vast majority of states, Colorado puts the burden of proof on the prosecution, rather than on the defense. That means prosecutors will have to prove that Holmes is not insane, which could be an arduous task in a case involving so many unusual variables, such as Holmes? bomb-rigged apartment, his orange-dyed hair, reports he told the police he was the cartoon villain the Joker, his heavy reliance on a psychiatrist and prescription medicine, and so forth.

Even faced with that task, however, the prosecution will not have a difficult case in proving Holmes knew what he was doing, says Daniel Filler, a former public defender who teaches criminal law at Drexel University School of Law in Philadelphia.

?While formally the burden of proof is on the prosecution, the reality is that juries are not typically very sympathetic to insanity claims,? Professor Filler says. ?It is important to distinguish the formal rules of law and what the practical challenges are. The reality is the prosecution has the winds at its back in arguing [Holmes] is not insane because, after a horrible crime, juries are not looking for a way to absolve the defendant.?

The trial will ultimately come down to ?a battle of experts,? he adds.

Arapahoe County prosecutor George Brauchler has said he will announce Monday whether he intends to seek the death penalty. There are clues that suggest he might be leaning toward that option. Mr. Brauchler added a death penalty lawyer to the prosecution team last month, and all three people on Colorado's death row were tried and sentenced in Arapahoe County.

The Holmes case has come as Colorado debated becoming the 18th state to repeal the death penalty. Though polls suggest that 68 percent of Coloradans support the death penalty, the legislature apparently had the votes to pass a bill. At a recent legislative hearing, Mr. Brauchler argued against repealing the sanction, saying, ?repeal of the death penalty makes it harder to find justice for the worst-of-the-worst cases.?

Earlier this week, Gov. John Hickenlooper said he would veto a bill to repeal the death penalty and support for the bill fell apart. It failed to pass a committee vote Tuesday.

Though the bill would not have affected the Holmes case ? it would have applied only to crimes committed after July 1, 2013 ? some experts suggest that it has? kept the issue before the public eye.

"The Holmes case is no doubt keeping the issue on the death penalty in Colorado because of his very visible prosecution," says Kyle Saunders, a political scientist at Colorado State University in Fort Collins, in an e-mail.

Colorado has not executed a person since 1977.

? Staff writer Patrik Jonsson contributed to this report.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/d_fiKFhHu3Q/James-Holmes-plea-rejected-Are-prosecutors-prepping-for-death-penalty

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Remains of the Day: Gmail's New Compose Window Comes to Everyone

Remains of the Day: Gmail's New Compose Window Comes to EveryoneGmail makes its new compose feature standard, Amazon acquires Goodreads, Google starts testing its same day delivery service, and Facebook Messenger gets free calling in the UK.

  • Gmail's New Compose Now Default Gmail's new compose window, which allows you to write new emails in an overlaid chat-like window, is now the default setting for all users. The old Compose window is still accessible, but only as a temporary setting. [Gmail]
  • Exciting News About Goodreads: We're Joining the Amazon Family! Book recommendation/community site Goodreads was acquired by Amazon today. Goodreads will continue to run and exist as its own entity, but expect to see the site's social features and recommendations make their way to Kindle in the near future. [Goodreads]
  • Calling All SF Bay Area Residents: Help Test Our New Local, Same-Day Delivery Service Today Google announced that it will be testing a new service, Google Shopping Express, in the San Francisco Bay Area. The service will allow users to order online from both national and local retailers and have their purchases delivered on the same day. [Google Commerce]
  • Facebook Quietly Begins Rolling Out Free Voice Calling In Messenger App For UK Residents Facebook Messenger users in the UK received an update that brings free VoIP calling to the app. The feature came to US users in January, and remains exclusive to the Messenger app as opposed to the main Facebook app. [The Next Web]
  • Raspbmc's March Update The latest update to the Raspberry Pi media center app improves AirPlay visibility for Mac OS and iOS 8 and comes with a large number of bug fixes. [Raspbmc]
  • Introducing GNOME 3.8 Linux desktop environment GNOME released its latest version this week. The new release comes with a large number of new features like a new app launcher, improved search, and better privacy controls. Also in the release is Classic Mode, which will let users switch to a more traditional GNOME 2-like interface. [Gnome Library]

Photo by photastic (Shutterstock), a2bb5s (Shutterstock), and Feng Yu (Shutterstock).

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/9TyDLMQX8bg/remains-of-the-day-gmails-new-compose-window-comes-to-everyone

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Samsung Galaxy S 4 for Verizon swings through the FCC

Samsung Galaxy S 4 for Verizon swings through the FCC

We weren't kidding about that influx of FCC filings: the Verizon edition of Samsung's Galaxy S 4, the SCH-i545, has passed through the US regulator's approval right on cue. The device on display ticks all the checkboxes we'd expect, including LTE on both Verizon's main 700MHz band and the carrier's recently acquired AWS frequencies. We also notice HSPA-based 3G, which suggests Big Red's GS4 won't be a paperweight when abroad. The filing just leaves AT&T and T-Mobile as the major stragglers in the US; at the current rate, though, they'll have little trouble getting clearance before they have to fulfill any future orders.

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Source: FCC

Source: http://www.engadget.com/2013/03/29/samsung-galaxy-s-4-for-verizon-swings-through-the-fcc/

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Drone industry worries about privacy backlash

(AP) ? It's a good bet that in the not-so-distant future aerial drones will be part of Americans' everyday lives, performing countless useful functions.

A far cry from the killing machines whose missiles incinerate terrorists, these generally small, unmanned aircraft will help farmers more precisely apply water and pesticides to crops, saving money and reducing environmental impacts. They'll help police departments find missing people, reconstruct traffic accidents and act as lookouts for SWAT teams. They'll alert authorities to people stranded on rooftops by hurricanes and monitor evacuation flows.

Real estate agents will use them to film videos of properties and surrounding neighborhoods. States will use them to inspect bridges, roads and dams. Oil companies will use them to monitor pipelines, while power companies use them to monitor transmission lines.

With military budgets shrinking, drone makers have been counting on the civilian market to spur the industry's growth. But there's an ironic threat to that hope: Success on the battlefield may contain the seeds of trouble for the more benign uses of drones at home.

The civilian unmanned aircraft industry worries that it will be grounded before it can really take off because of fear among the public that the technology will be misused. Also problematic is a delay in the issuance of government safety regulations that are needed before drones can gain broad access to U.S. skies.

Some companies that make drones or supply support equipment and services say the uncertainty has caused them to put U.S. expansion plans on hold, and they are looking overseas for new markets.

"Our lack of success in educating the public about unmanned aircraft is coming back to bite us," said Robert Fitzgerald, CEO of The BOSH Group of Newport News, Va., which provides support services to drone users.

"The U.S. has been at the lead of this technology a long time," he said. "If our government holds back this technology, there's the freedom to move elsewhere ... and all of a sudden these things will be flying everywhere else and competing with us."

Since January, drone-related legislation has been introduced in more than 30 states, largely in response to privacy concerns. Many of the bills are focused on preventing police from using drones for broad public surveillance, as well as targeting individuals for surveillance without sufficient grounds to believe they were involved in crimes.

Law enforcement is expected to be one of the bigger initial markets for civilian drones. Last month, the FBI used drones to maintain continuous surveillance of a bunker in Alabama where a 5-year-old boy was being held hostage.

In Virginia, the state General Assembly passed a bill that would place a two-year moratorium on the use of drones by state and local law enforcement. The measure is supported by groups as varied as the American Civil Liberties Union on the left and the Virginia Tea Party Patriots Federation on the right.

Gov. Bob McDonnell is proposing amendments that would retain the broad ban on spy drones but allow specific exemptions when lives are in danger, such as for search-and rescue operations. The legislature reconvenes on April 3 to consider the amendments.

"Any legislation that restricts the use of this kind of capability to serve the public is putting the public at risk," said Steve Gitlin, vice president of AeroVironment, a leading maker of smaller drones, including some no bigger than a hummingbird

Seattle abandoned its drone program after community protests in February. The city's police department had purchased two drones through a federal grant without consulting the city council.

Drones "clearly have so much potential for saving lives, and it's a darn shame we're having to go through this right now," said Stephen Ingley, executive director of the Airborne Law Enforcement Association. "It's frustrating."

In some states economic concerns have trumped public unease. In Oklahoma, an anti-drone bill was shelved at the request of Republican Gov. Mary Fallin, who was concerned it might hinder growth of the state's drone industry. The North Dakota state Senate killed a drone bill in part because of concern that it might impede the state's chances of being selected by the Federal Aviation Administration as one of six national drone test sites, which could generate local jobs.

A bill that would have limited the ability of state and local governments to use drones died in the Washington legislature. The measure was opposed by The Boeing Co., which employs more than 80,000 workers in the state and which has a subsidiary, Insitu, that's a leading military drone manufacturer.

Although the Supreme Court has not dealt directly with drones, it has OK'd aerial surveillance without warrants in drug cases in which officers in a plane or helicopter spotted marijuana plants growing on a suspect's property. But in a case involving the use of ground-based equipment, the court said police generally need a warrant before using a thermal imaging device to detect hot spots in a home that might indicate that marijuana plants are being grown there.

In Congress, Rep. Ed Markey, D-Mass., co-chairman of the House's privacy caucus, has introduced a bill that prohibits the Federal Aviation Administration from issuing drone licenses unless the applicant provides a statement explaining who will operate the drone, where it will be flown, what kind of data will be collected, how the data will be used, whether the information will be sold to third parties and the period for which the information will be retained.

Sentiment for curbing domestic drone use has brought the left and right together perhaps more than any other recent issue. "The thought of government drones buzzing overhead and constantly monitoring the activities of law-abiding citizens runs contrary to the notion of what it means to live in a free society," Sen. Charles Grassley, R-Iowa, said at a recent hearing of the Senate Judiciary Committee.

Privacy advocates acknowledge the many good uses of drones. In Mesa County, Colo., for example, an annual landfill survey using manned aircraft cost about $10,000. The county recently performed the same survey using a drone for about $200.

But drones' virtues can also make them dangerous, they say. Their low cost and ease of use may encourage police and others to conduct the kind of continuous or intrusive surveillance that might otherwise be impractical. Drones can be equipped with high-powered cameras and listening devices, and infrared cameras that can see people in the dark.

"High-rise buildings, security fences or even the walls of a building are not barriers to increasingly common drone technology," Amie Stepanovich, director of the Electronic Privacy Information Council's surveillance project, told the Senate panel.

Civilian drone use is limited to government agencies and public universities that have received a few hundred permits from the FAA. A law passed by Congress last year requires the FAA to open U.S. skies to widespread drone flights by 2015, but the agency is behind schedule and it's doubtful it will meet that deadline. Lawmakers and industry officials have complained for years about the FAA's slow progress.

The FAA estimates that within five years of gaining broader access about 7,500 civilian drones will be in use.

Sen. Rand Paul, R-Ky., recently drew attention to the domestic use of drones when he staged a Senate filibuster, demanding to know whether the president has authority to use weaponized drones to kill Americans on American soil. The White House said no, if the person isn't engaged in combat. But industry officials worry that the episode could temporarily set back civilian drone use.

"The opposition has become very loud," said Gitlin of AeroVironment, "but we are confident that over time the benefits of these solutions (drones) are going to far outweigh the concerns, and they'll become part of normal life in the future."

___

Associated Press writer Michael Felberbaum in Richmond, Va., contributed to this report.

___

Follow Joan Lowy on Twitter: http://www.twitter.com/AP_Joan_Lowy

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-03-29-Everyday%20Drones/id-aaae4985408342848295f731e6ad3aa9

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Friday, March 29, 2013

Stanford survey: Americans back preparation for extreme weather and sea-level rise

Stanford survey: Americans back preparation for extreme weather and sea-level rise [ Back to EurekAlert! ] Public release date: 28-Mar-2013
[ | E-mail | Share Share ]

Contact: Terry Nagel, Stanford
tnagel@stanford.edu
650-498-0607
Stanford University

Images told the story: lower Manhattan in darkness, coastal communities washed away, cars floating in muck. Superstorm Sandy, a harbinger of future extreme weather intensified by climate change, caught the country off guard in October.

Unprepared for the flooding and high winds that ensued, the East Coast suffered more than $70 billion in property damage and more than 100 deaths.

Will Americans prepare and invest now to minimize the impact of disasters such as Sandy, or deal with storms and rising sea levels after they occur?

A new survey commissioned by the Stanford Woods Institute for the Environment and the Center for Ocean Solutions finds that an overwhelming majority of Americans want to prepare in order to minimize the damage likely to be caused by global warming-induced sea-level rise and storms.

A majority also wants people whose properties and businesses are located in hazard areas to foot the bill for this preparation, not the government. Eighty-two percent of the Americans surveyed said that people and organizations should prepare for the damage likely to be caused by sea-level rise and storms, rather than simply deal with the damage after it happens.

Among the most popular policy solutions identified in the survey are stronger building codes for new structures along the coast to minimize damage (favored by 62 percent) and preventing new buildings from being built near the coast (supported by 51 percent).

"People support preventive action," said survey director Jon Krosnick, a senior fellow at the Stanford Woods Institute for the Environment and professor of communication, "and few people believe these preparations will harm the economy or eliminate jobs. In fact, more people believe that preparation efforts will help the economy and create jobs around the U.S., in their state and in their town than think these efforts will harm the economy and result in fewer jobs in those areas. But people want coastal homeowners and businesses that locate in high-risk areas to pay for these measures."

The challenges posed by rising sea levels and increasingly severe storms will only intensify as more Americans build along the coasts. A National Oceanic and Atmospheric Administration report released March 25 predicts that already crowded U.S. coastlines will become home to an additional 11 million people by 2020.

Survey questions were formulated to assess participants' beliefs about climate change and gather opinions about the impact of climate change, sea-level rise and storms on communities, the economy and jobs.

The survey also gauged public support for specific coastal adaptation strategies and how to pay for them. "People are least supportive of policies that try to hold back Mother Nature," Krosnick said. "They think it makes more sense to recognize risk and reduce exposure."

Among the survey's respondents, 48 percent favor sand dune restoration and 33 percent favor efforts to maintain beaches with sand replenishment, while 37 percent support relocating structures away from the coast and 33 percent support constructing sea walls.

Eighty-two percent of the survey's respondents believe that Earth's temperature has been rising over the last 100 years. However, even a majority of those who doubt the existence of climate change favor adaptation measures (60 percent).

"The question is, how does public support for preparation translate to action?" asked Meg Caldwell, executive director of the Center for Ocean Solutions. "Our impulse is to try to move quickly to put communities back together the way they were after devastation. But that impulse often leads to doubling down on high-risk investments, such as rebuilding in areas likely to experience severe impacts. To move toward long-term resiliency for coastal communities, we need to seize opportunities to apply new thinking, new standards and long-term solutions."

Krosnick presented the survey results this morning at a policy briefing hosted by the Stanford Woods Institute for the Environment at the National Press Club in Washington, D.C.

The briefing was followed by a discussion about the implications of changing public attitudes with four panelists: Cas Holloway, deputy mayor for operations in New York City; Laurie McGilvray, chief of the Estuarine Reserves Division of the National Oceanic and Atmospheric Administration; Margaret Peloso, an attorney with the international law firm of Vinson & Elkins; and Carol Werner, the executive director of the Environmental and Energy Study Institute. Videos of the presentation and the panel discussion will be available by 4 p.m. Eastern/1 p.m. Pacific time on the Stanford Woods Institute website.

The survey was conducted via the Internet with a nationally representative probability sample of 1,174 American adults, 18 and older, conducted by GfK Custom Research March 3-18, 2013. The survey was administrated in both English and Spanish. The survey has a margin of error of +/-4.9 percent at the 95 percent confidence level.

###

Bo MacInnis, a visiting scholar at Stanford University's Department of Communication, was co-director of the study. Lauren Howe, a graduate student in psychology at Stanford; Adina Abeles, director of education and training at the Stanford Center for Ocean Solutions; Ezra Markowitz, a postdoctoral fellow at Princeton University; and Robert Socolow, director of the Princeton University Environmental Institute's Climate and Energy Challenge, contributed to the survey design and analysis process.


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Stanford survey: Americans back preparation for extreme weather and sea-level rise [ Back to EurekAlert! ] Public release date: 28-Mar-2013
[ | E-mail | Share Share ]

Contact: Terry Nagel, Stanford
tnagel@stanford.edu
650-498-0607
Stanford University

Images told the story: lower Manhattan in darkness, coastal communities washed away, cars floating in muck. Superstorm Sandy, a harbinger of future extreme weather intensified by climate change, caught the country off guard in October.

Unprepared for the flooding and high winds that ensued, the East Coast suffered more than $70 billion in property damage and more than 100 deaths.

Will Americans prepare and invest now to minimize the impact of disasters such as Sandy, or deal with storms and rising sea levels after they occur?

A new survey commissioned by the Stanford Woods Institute for the Environment and the Center for Ocean Solutions finds that an overwhelming majority of Americans want to prepare in order to minimize the damage likely to be caused by global warming-induced sea-level rise and storms.

A majority also wants people whose properties and businesses are located in hazard areas to foot the bill for this preparation, not the government. Eighty-two percent of the Americans surveyed said that people and organizations should prepare for the damage likely to be caused by sea-level rise and storms, rather than simply deal with the damage after it happens.

Among the most popular policy solutions identified in the survey are stronger building codes for new structures along the coast to minimize damage (favored by 62 percent) and preventing new buildings from being built near the coast (supported by 51 percent).

"People support preventive action," said survey director Jon Krosnick, a senior fellow at the Stanford Woods Institute for the Environment and professor of communication, "and few people believe these preparations will harm the economy or eliminate jobs. In fact, more people believe that preparation efforts will help the economy and create jobs around the U.S., in their state and in their town than think these efforts will harm the economy and result in fewer jobs in those areas. But people want coastal homeowners and businesses that locate in high-risk areas to pay for these measures."

The challenges posed by rising sea levels and increasingly severe storms will only intensify as more Americans build along the coasts. A National Oceanic and Atmospheric Administration report released March 25 predicts that already crowded U.S. coastlines will become home to an additional 11 million people by 2020.

Survey questions were formulated to assess participants' beliefs about climate change and gather opinions about the impact of climate change, sea-level rise and storms on communities, the economy and jobs.

The survey also gauged public support for specific coastal adaptation strategies and how to pay for them. "People are least supportive of policies that try to hold back Mother Nature," Krosnick said. "They think it makes more sense to recognize risk and reduce exposure."

Among the survey's respondents, 48 percent favor sand dune restoration and 33 percent favor efforts to maintain beaches with sand replenishment, while 37 percent support relocating structures away from the coast and 33 percent support constructing sea walls.

Eighty-two percent of the survey's respondents believe that Earth's temperature has been rising over the last 100 years. However, even a majority of those who doubt the existence of climate change favor adaptation measures (60 percent).

"The question is, how does public support for preparation translate to action?" asked Meg Caldwell, executive director of the Center for Ocean Solutions. "Our impulse is to try to move quickly to put communities back together the way they were after devastation. But that impulse often leads to doubling down on high-risk investments, such as rebuilding in areas likely to experience severe impacts. To move toward long-term resiliency for coastal communities, we need to seize opportunities to apply new thinking, new standards and long-term solutions."

Krosnick presented the survey results this morning at a policy briefing hosted by the Stanford Woods Institute for the Environment at the National Press Club in Washington, D.C.

The briefing was followed by a discussion about the implications of changing public attitudes with four panelists: Cas Holloway, deputy mayor for operations in New York City; Laurie McGilvray, chief of the Estuarine Reserves Division of the National Oceanic and Atmospheric Administration; Margaret Peloso, an attorney with the international law firm of Vinson & Elkins; and Carol Werner, the executive director of the Environmental and Energy Study Institute. Videos of the presentation and the panel discussion will be available by 4 p.m. Eastern/1 p.m. Pacific time on the Stanford Woods Institute website.

The survey was conducted via the Internet with a nationally representative probability sample of 1,174 American adults, 18 and older, conducted by GfK Custom Research March 3-18, 2013. The survey was administrated in both English and Spanish. The survey has a margin of error of +/-4.9 percent at the 95 percent confidence level.

###

Bo MacInnis, a visiting scholar at Stanford University's Department of Communication, was co-director of the study. Lauren Howe, a graduate student in psychology at Stanford; Adina Abeles, director of education and training at the Stanford Center for Ocean Solutions; Ezra Markowitz, a postdoctoral fellow at Princeton University; and Robert Socolow, director of the Princeton University Environmental Institute's Climate and Energy Challenge, contributed to the survey design and analysis process.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/su-ssa032813.php

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Northern Vertex Announces PEA for the Moss Mine Gold-Silver Project

?Northern Vertex Mining Corp. (TSXV:NEE) released the results of a preliminary economic assessment for its Moss Mine Gold-Silver Project in Mohave County Arizona, USA: Pre-Tax IRR 117.9%, NPV @5% $110 Million USD, Payback Period 1.25 Years.

As quoted in the press release:

Highlights are as follows:

Mine life 5 yrs, 5000 tpd, 42,000 AuEq oz/yr
Pre-tax IRR of 117.9%
Pre-tax payback of 15 months
Pre-tax NPV @5% $110 million
Capital expenditures $26.6 million
Capital / average annual oz AuEq production $633/oz
Cash Costs/oz AuEq $490/oz

Click here to read the Northern Vertex Mining Corp. (TSXV:NEE) press release

See this press release on Marketwire
Click here to see the Northern Vertex Mining Corp. (TSXV:NEE) profile.

Source: http://goldinvestingnews.com/33503/northern-vertex-announces-pea-for-the-moss-mine-gold-silver-project.html

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Satellite communication Technology Development | myownblog

Satellites have been orbiting the earth amazing decades now, And are constantly resulting in the evolution of global communication.

Satellite cell Replica Girard Perregaux Watches phones have made it possible for people to make phone calls from from any location, No matter how remote their whereabouts, And have been extremely useful in coordination of many activities cover anything from scientific exploration to military operations.

Portable satellite radio is another significant benefit of technology that has emerged in recent years, Allowing users to subscribe to and access radio channels from everywhere for either entertainment or informational purposes.

One small problem with satellite communication technology, then again, Is the sheer distance involved in mingling with orbiting satellites, Which can cause a slight Rolex Sea Dweller Fake Watches delay in sign time. this kind of, needless to, Is of no conclusion to satellite radio, But it could be a slight problem for two-Way communication software program as broadband and phone.

the only method to reduce the time delay involved in satellite transmission is to use lower orbits for satellites, De Witt Replica Thus reducing the distance involved in transmitting. Lower orbits happen to be being used for some purposes, But there are many challenges that must be overcome in order to make such a transition.

Advancements in satellite technology have been plentiful in recent years, And more are expected later on in life. It will be very interesting to watch the roll-out of this evolving technology over the coming years and beyond

Source: http://lockierstayle.edublogs.org/2013/03/28/satellite-communication-technology-development/

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New type of solar structure cools buildings in full sunlight

Mar. 27, 2013 ? A Stanford team has designed an entirely new form of cooling panel that works even when the sun is shining. Such a panel could vastly improve the daylight cooling of buildings, cars and other structures by radiating sunlight back into the chilly vacuum of space.

Homes and buildings chilled without air conditioners. Car interiors that don't heat up in the summer sun. Tapping the frigid expanses of outer space to cool the planet. Science fiction, you say? Well, maybe not any more.

A team of researchers at Stanford has designed an entirely new form of cooling structure that cools even when the sun is shining. Such a structure could vastly improve the daylight cooling of buildings, cars and other structures by reflecting sunlight back into the chilly vacuum of space. Their paper describing the device was published March 5 in Nano Letters.

"People usually see space as a source of heat from the sun, but away from the sun outer space is really a cold, cold place," explained Shanhui Fan, professor of electrical engineering and the paper's senior author. "We've developed a new type of structure that reflects the vast majority of sunlight, while at the same time it sends heat into that coldness, which cools humanmade structures even in the day time."

The trick, from an engineering standpoint, is two-fold. First, the reflector has to reflect as much of the sunlight as possible. Poor reflectors absorb too much sunlight, heating up in the process and defeating the purpose of cooling.

The second challenge is that the structure must efficiently radiate heat back into space. Thus, the structure must emit thermal radiation very efficiently within a specific wavelength range in which the atmosphere is nearly transparent. Outside this range, Earth's atmosphere simply reflects the light back down. Most people are familiar with this phenomenon. It's better known as the greenhouse effect -- the cause of global climate change.

Two goals in one

The new structure accomplishes both goals. It is an effective a broadband mirror for solar light -- it reflects most of the sunlight. It also emits thermal radiation very efficiently within the crucial wavelength range needed to escape Earth's atmosphere.

Radiative cooling at nighttime has been studied extensively as a mitigation strategy for climate change, yet peak demand for cooling occurs in the daytime.

"No one had yet been able to surmount the challenges of daytime radiative cooling -- of cooling when the sun is shining," said Eden Rephaeli, a doctoral candidate in Fan's lab and a co-first-author of the paper. "It's a big hurdle."

The Stanford team has succeeded where others have come up short by turning to nanostructured photonic materials. These materials can be engineered to enhance or suppress light reflection in certain wavelengths.

"We've taken a very different approach compared to previous efforts in this field," said Aaswath Raman, a doctoral candidate in Fan's lab and a co-first-author of the paper. "We combine the thermal emitter and solar reflector into one device, making it both higher performance and much more robust and practically relevant. In particular, we're very excited because this design makes viable both industrial-scale and off-grid applications."

Using engineered nanophotonic materials the team was able to strongly suppress how much heat-inducing sunlight the panel absorbs, while it radiates heat very efficiently in the key frequency range necessary to escape Earth's atmosphere. The material is made of quartz and silicon carbide, both very weak absorbers of sunlight.

Net cooling power

The new device is capable of achieving a net cooling power in excess of 100 watts per square meter. By comparison, today's standard 10-percent-efficient solar panels generate the about the same amount of power. That means Fan's radiative cooling panels could theoretically be substituted on rooftops where existing solar panels feed electricity to air conditioning systems needed to cool the building.

To put it a different way, a typical one-story, single-family house with just 10 percent of its roof covered by radiative cooling panels could offset 35 percent its entire air conditioning needs during the hottest hours of the summer.

Radiative cooling has another profound advantage over all other cooling strategy such as air-conditioner. It is a passive technology. It requires no energy. It has no moving parts. It is easy to maintain. You put it on the roof or the sides of buildings and it starts working immediately.

A changing vision of cooling

Beyond the commercial implications, Fan and his collaborators foresee a broad potential social impact. Much of the human population on Earth lives in sun-drenched regions huddled around the equator. Electrical demand to drive air conditioners is skyrocketing in these places, presenting an economic and an environmental challenge. These areas tend to be poor and the power necessary to drive cooling usually means fossil-fuel power plants that compound the greenhouse gas problem.

"In addition to these regions, we can foresee applications for radiative cooling in off-the-grid areas of the developing world where air conditioning is not even possible at this time. There are large numbers of people who could benefit from such systems," Fan said.

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Story Source:

The above story is reprinted from materials provided by Stanford School of Engineering. The original article was written by Andrew Myers.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Eden Rephaeli, Aaswath Raman, Shanhui Fan. Ultrabroadband Photonic Structures To Achieve High-Performance Daytime Radiative Cooling. Nano Letters, 2013; : 130311121615001 DOI: 10.1021/nl4004283

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/STQ2QlQf-MY/130327132544.htm

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Thursday, March 28, 2013

Kidney stone surgery: More women, more complications with minimally invasive procedure

Kidney stone surgery: More women, more complications with minimally invasive procedure [ Back to EurekAlert! ] Public release date: 27-Mar-2013
[ | E-mail | Share Share ]

Contact: Dwight Angell
dwight.angell@hfhs.org
313-850-3471
Henry Ford Health System

DETROIT While the number of people especially women who have a minimally invasive procedure to remove kidney stones has risen in recent years, so has the rate of complications related to the surgery, according to a published study by Henry Ford Hospital.

The research, from Khurshid R. Ghani, M.D., of Henry Ford Hospital's Vattikuti Urology Institute, appears in the current issue of Journal of Urology.

The focus of the investigation was the procedure, percutaneous nephrolithotomy, or PCNL, in which a surgeon removes medium to large kidney stones through a small incision in the back using a hollow scope.

Minimally invasive procedures used for treating a wide range of medical conditions have increased in recent years, and the Henry Ford researchers set out to find how much and to what effect this is true for this specific procedure.

"What we found is that the use of PCNL in this country has increased," Dr. Ghani said, "and more women than men have the procedure.

"We also discovered that while the rate of PCNL-related death is low and has remained so, incidence of blood infection and overall complications has increased."

The population-based study looked at data from the Nationwide Inpatient Sample, a database of inpatient hospital stays used by researchers to find, track and analyze national health care trends. The database catalogs some 8 million cases from more than 1,000 hospitals in 44 states.

It was used in this study to identify patients who underwent PCNL between 1999 and 2009. A weighted sample was then formulated to estimate utilization rates across the country.

In addition, Henry Ford researchers tracked and analyzed trends in patient age; complications before, during and after the procedure; other disorders or diseases that existed at the time of the surgery; and in-hospital deaths.

A total of 80,097 patients over the age of 18 and with a median age of 53 were found to have undergone PCNL during the study period, during which the number of times the procedure was performed climbed by 47 percent.

The results showed:

  • PCNL use rose from 3.0 to 3.63 per 100,000 men, and from 2.99 to 4.07 per 100,000 women during the study period. This represented a 0.03 percent increase in men who underwent the procedure compared to a 2.54 percent increase in women.
  • Co-morbidity, or the presence of other disorders or disease at the time of surgery, increased during the study time-span.
  • At the same time, overall complications increased from 12.2 percent in 1999 to 15.6 percent in 2009.
  • Significantly, the incidence of sepsis or blood infection doubled, rising from 1.2 percent to 2.4 percent.
  • The rate of PCNL-related death remained essentially unchanged at 0 to 0.4 percent.

Dr. Ghani and his associates concluded that patients were at higher risk of developing complications if they were older, sicker and treated in more recent years. And though the rate of deaths associated with the procedure remained statistically flat, those cases that did occur were found with older patients.

"We believe the broad use of this procedure, especially in older and sicker patients, may be the reason for these changes," Dr. Ghani said.

###



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Kidney stone surgery: More women, more complications with minimally invasive procedure [ Back to EurekAlert! ] Public release date: 27-Mar-2013
[ | E-mail | Share Share ]

Contact: Dwight Angell
dwight.angell@hfhs.org
313-850-3471
Henry Ford Health System

DETROIT While the number of people especially women who have a minimally invasive procedure to remove kidney stones has risen in recent years, so has the rate of complications related to the surgery, according to a published study by Henry Ford Hospital.

The research, from Khurshid R. Ghani, M.D., of Henry Ford Hospital's Vattikuti Urology Institute, appears in the current issue of Journal of Urology.

The focus of the investigation was the procedure, percutaneous nephrolithotomy, or PCNL, in which a surgeon removes medium to large kidney stones through a small incision in the back using a hollow scope.

Minimally invasive procedures used for treating a wide range of medical conditions have increased in recent years, and the Henry Ford researchers set out to find how much and to what effect this is true for this specific procedure.

"What we found is that the use of PCNL in this country has increased," Dr. Ghani said, "and more women than men have the procedure.

"We also discovered that while the rate of PCNL-related death is low and has remained so, incidence of blood infection and overall complications has increased."

The population-based study looked at data from the Nationwide Inpatient Sample, a database of inpatient hospital stays used by researchers to find, track and analyze national health care trends. The database catalogs some 8 million cases from more than 1,000 hospitals in 44 states.

It was used in this study to identify patients who underwent PCNL between 1999 and 2009. A weighted sample was then formulated to estimate utilization rates across the country.

In addition, Henry Ford researchers tracked and analyzed trends in patient age; complications before, during and after the procedure; other disorders or diseases that existed at the time of the surgery; and in-hospital deaths.

A total of 80,097 patients over the age of 18 and with a median age of 53 were found to have undergone PCNL during the study period, during which the number of times the procedure was performed climbed by 47 percent.

The results showed:

  • PCNL use rose from 3.0 to 3.63 per 100,000 men, and from 2.99 to 4.07 per 100,000 women during the study period. This represented a 0.03 percent increase in men who underwent the procedure compared to a 2.54 percent increase in women.
  • Co-morbidity, or the presence of other disorders or disease at the time of surgery, increased during the study time-span.
  • At the same time, overall complications increased from 12.2 percent in 1999 to 15.6 percent in 2009.
  • Significantly, the incidence of sepsis or blood infection doubled, rising from 1.2 percent to 2.4 percent.
  • The rate of PCNL-related death remained essentially unchanged at 0 to 0.4 percent.

Dr. Ghani and his associates concluded that patients were at higher risk of developing complications if they were older, sicker and treated in more recent years. And though the rate of deaths associated with the procedure remained statistically flat, those cases that did occur were found with older patients.

"We believe the broad use of this procedure, especially in older and sicker patients, may be the reason for these changes," Dr. Ghani said.

###



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/hfhs-kss032613.php

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Obama implores Congress to enact gun reforms

President Barack Obama addresses gun violence on March 28. (Yuri Gripas/Reuters)President Barack Obama spoke at the White House with rows of grieving mothers behind him and publicly implored Congress to pass gun-reform legislation 100 days after the Sandy Hook Elementary School mass shootings in Newtown, Conn.

"We've cried enough. We've known enough heartbreak. ... It's something that if we are serious, we will do," Obama said, Vice President Joe Biden at his side. "Now is the time to turn that heartbreak into something real."

As the mothers of children killed by gun violence wiped away tears, the president went on to urge the passage of background checks for gun buyers, and for loopholes to be closed for buyers who turn around and sell guns to criminals. He said 90 percent of Americans support background checks, as well as 80 percent of gun owners and 80 percent of Republicans.

Obama also suggested that too much time has passed since the shootings at Newtown. "Shame on us if we've forgotten. I haven't forgotten those kids. Shame on us if we've forgotten," the president said.

Later on Thursday, at the White Press briefing, Principal Deputy Press Secretary Josh Earnest addressed questions regarding timing and whether the president himself has acted swiftly enough on gun reform: "The president, I think, has been very forward-leaning in terms of the way he's engaged in this process."

Earnest also noted the 23 executive actions released by the White House in January and the more than 20 events and conversations with lawmakers, community leaders, survivors and gun-related groups the White House has undertaken in the days since Newtown.

But what many consider to be the most contentious proposed gun-reform legislation, an assault weapons ban, was absent from the president's remarks on Thursday.

Senate Democrats working on gun-reform legislation recently announced that they would drop an assault weapons ban from an overall package of reform measures and put it to a separate vote as an amendment. That action is designed to boost the chances a reform package will pass, as it's expected that the ban is too unpalatable for some members, especially Democrats in gun rights states and the multitude of Republican opponents.

The White House has been casting a positive spin on that decision, suggesting that offering the ban as an amendment still forces lawmakers to choose sides on the issue, even if it doesn't win passage.

"I can't stand here and guarantee that it?s going to pass," Earnest said at Wednesday's press briefing, "but it is a question that 100 senators are going to ask themselves when they wake up in the morning and look themselves in the mirror about whether or not they are going to?about which side they're going to be on when it comes to voting on a ban on military-style assault weapons." He added that the president will continue to advocate for the ban.

Democrats in Congress concede separating the ban from the overall package is the best way forward.

"We want to come out with the best, the boldest common denominator that we can get," House Minority Leader Nancy Pelosi said at a news conference on Wednesday when asked about the decision to separate an assault weapons ban.

Senate Majority Leader Harry Reid has stated plans to introduce a gun-reform bill next month.

In addition to the president's talk, activities related to gun reform are taking place across the country on Thursday, a day gun-reform advocates have marked the "National Day to Demand Action" to end gun violence.

New York City Mayor Michael Bloomberg?s anti-gun group, Mayors Against Illegal Guns, released two television ads on Thursday featuring family members of those killed in Newtown.

Court documents released on Thursday revealed, among other things, that police investigating the Sandy Hook massacre seized samurai swords, as well as a massive amount of ammunition and books on guns and mental health from the home of gunman Adam Lanza.

?

Source: http://news.yahoo.com/blogs/ticket/obama-urges-congress-pass-universal-background-checks-close-162559887--politics.html

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Study Links Early Baldness to Prostate Cancer in African Americans (Voice Of America)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/295238055?client_source=feed&format=rss

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Wednesday, March 27, 2013

NYU Dentistry and Medicine are awarded a $840,864 collaborative grant by the Lustgarten Foundation

NYU Dentistry and Medicine are awarded a $840,864 collaborative grant by the Lustgarten Foundation [ Back to EurekAlert! ] Public release date: 26-Mar-2013
[ | E-mail | Share Share ]

Contact: Christopher James
christopher.james@nyu.edu
212-998-6876
New York University

'The Role of the Intestinal Microbiome in Promoting Pancreatic Carcinogenesis'

New York University College of Dentistry (NYUCD) and New York University School of Medicine (SOM) researchers have been awarded a four-year $840,864 collaborative grant by the Lustgarten Foundation to investigate a potential link between pancreatic cancer development and endogenous gut microbiota.

The co-investigators, Deepak Saxena, MS, PhD, Assistant Professor, Basic Science and Craniofacial Biology at NYUCD, and George Miller, MD, Assistant Professor; Departments of Surgery and Cell Biology at the SOM, seek to explore the links between the intestinal microbiome, Toll-like receptors (TLRs), and pancreatic cancer.

"Endogenous gut microbiota have recently been appreciated as important regulators of homeostasis in the healthy individual and contributors toward disease during microbiotic imbalance," said Saxena. "The microbiome is also emerging as a contributor to carcinogenesis in extra-pancreatic malignancies such as colon and liver cancer. However, there has been no direct link between pancreatic cancer development and endogenous gut microbiota," he noted.

There are tangential data, however, that support such an association. For example, the oral microbiome in patients with pancreatic cancer has been found to substantially differ from control subjects. Preliminary data suggest that the intestinal microbiome may be an important regulator of pancreatic cancer development in at-risk individuals.

The study proposes to:

  • Define the evolving intestinal microbiome in mice during pancreatic cancer development and progression as well as determine whether humans with pancreatic cancer harbor a distinct microbiome compared with age-matched control patients
  • Directly test whether endoluminal bacteria can affect pancreatic oncogenesis and determine whether selectively modulating the microbiome alters the rate of tumor progression
  • Test the hypothesis that luminal pathogens affect pancreatic tumorigenesis specifically via TLR ligation

"Our experiments will provide critical new information on the mechanism of pancreatic carcinogenesis in at-risk hosts and, as such, will provide guidance for pancreatic cancer prevention and possibly treatment of incipient disease," said Saxena.

"Based on our past research, we postulate that specific pathogenic gut bacteria drive pancreatic carcinogenesis in at-risk individuals via TLR activation," said Miller.

As a part of their grant, Drs. Saxena and Miller will be attending and presenting at the annual Lustgarten Scientific Conference to be held October 20-22, 2013, at the Banbury Center on Long Island NY.

###

About New York University College of Dentistry--New York University College of Dentistry (NYUCD) is the third oldest and the largest dental school in the US, educating more than 8 percent of all dentists. NYUCD has a significant global reach and provides a level of national and international diversity among its students that is unmatched by any other dental school.

About the NYU School of Medicine --NYU School of Medicine (SOM) is one of the nation's preeminent academic institutions dedicated to achieving world class medical educational excellence. For 171 years, NYU School of Medicine has trained thousands of physicians and scientists who have helped to shape the course of medical history and enrich the lives of countless people. An integral part of NYU Langone Medical Center, the School of Medicine at its core is committed to improving the human condition through medical education, scientific research and direct patient care. The School also maintains academic affiliations with area hospitals, including Bellevue Hospital Center, one of the nation's finest municipal hospitals where its students, residents and faculty provide the clinical and emergency care to New York City's diverse population, which enhances the scope and quality of their medical education and training. Additional information about the NYU School of Medicine is available at http://school.med.nyu.edu/.

About the Lustgarten Foundation: To advance the scientific and medical research related to the diagnosis, treatment, cure and prevention of pancreatic cancer by: Increasing funding and support of research into the biological mechanisms and clinical strategies related to the prevention, diagnosis, and treatment of pancreatic cancer; Facilitating and enhancing the dialogue among members of the medical and scientific communities about basic and clinical research efforts that relate to pancreatic cancer; Heightening public awareness of pancreatic cancer diagnosis, treatment, and prevention and providing informational support for pancreatic cancer patients, their families, and friends.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


NYU Dentistry and Medicine are awarded a $840,864 collaborative grant by the Lustgarten Foundation [ Back to EurekAlert! ] Public release date: 26-Mar-2013
[ | E-mail | Share Share ]

Contact: Christopher James
christopher.james@nyu.edu
212-998-6876
New York University

'The Role of the Intestinal Microbiome in Promoting Pancreatic Carcinogenesis'

New York University College of Dentistry (NYUCD) and New York University School of Medicine (SOM) researchers have been awarded a four-year $840,864 collaborative grant by the Lustgarten Foundation to investigate a potential link between pancreatic cancer development and endogenous gut microbiota.

The co-investigators, Deepak Saxena, MS, PhD, Assistant Professor, Basic Science and Craniofacial Biology at NYUCD, and George Miller, MD, Assistant Professor; Departments of Surgery and Cell Biology at the SOM, seek to explore the links between the intestinal microbiome, Toll-like receptors (TLRs), and pancreatic cancer.

"Endogenous gut microbiota have recently been appreciated as important regulators of homeostasis in the healthy individual and contributors toward disease during microbiotic imbalance," said Saxena. "The microbiome is also emerging as a contributor to carcinogenesis in extra-pancreatic malignancies such as colon and liver cancer. However, there has been no direct link between pancreatic cancer development and endogenous gut microbiota," he noted.

There are tangential data, however, that support such an association. For example, the oral microbiome in patients with pancreatic cancer has been found to substantially differ from control subjects. Preliminary data suggest that the intestinal microbiome may be an important regulator of pancreatic cancer development in at-risk individuals.

The study proposes to:

  • Define the evolving intestinal microbiome in mice during pancreatic cancer development and progression as well as determine whether humans with pancreatic cancer harbor a distinct microbiome compared with age-matched control patients
  • Directly test whether endoluminal bacteria can affect pancreatic oncogenesis and determine whether selectively modulating the microbiome alters the rate of tumor progression
  • Test the hypothesis that luminal pathogens affect pancreatic tumorigenesis specifically via TLR ligation

"Our experiments will provide critical new information on the mechanism of pancreatic carcinogenesis in at-risk hosts and, as such, will provide guidance for pancreatic cancer prevention and possibly treatment of incipient disease," said Saxena.

"Based on our past research, we postulate that specific pathogenic gut bacteria drive pancreatic carcinogenesis in at-risk individuals via TLR activation," said Miller.

As a part of their grant, Drs. Saxena and Miller will be attending and presenting at the annual Lustgarten Scientific Conference to be held October 20-22, 2013, at the Banbury Center on Long Island NY.

###

About New York University College of Dentistry--New York University College of Dentistry (NYUCD) is the third oldest and the largest dental school in the US, educating more than 8 percent of all dentists. NYUCD has a significant global reach and provides a level of national and international diversity among its students that is unmatched by any other dental school.

About the NYU School of Medicine --NYU School of Medicine (SOM) is one of the nation's preeminent academic institutions dedicated to achieving world class medical educational excellence. For 171 years, NYU School of Medicine has trained thousands of physicians and scientists who have helped to shape the course of medical history and enrich the lives of countless people. An integral part of NYU Langone Medical Center, the School of Medicine at its core is committed to improving the human condition through medical education, scientific research and direct patient care. The School also maintains academic affiliations with area hospitals, including Bellevue Hospital Center, one of the nation's finest municipal hospitals where its students, residents and faculty provide the clinical and emergency care to New York City's diverse population, which enhances the scope and quality of their medical education and training. Additional information about the NYU School of Medicine is available at http://school.med.nyu.edu/.

About the Lustgarten Foundation: To advance the scientific and medical research related to the diagnosis, treatment, cure and prevention of pancreatic cancer by: Increasing funding and support of research into the biological mechanisms and clinical strategies related to the prevention, diagnosis, and treatment of pancreatic cancer; Facilitating and enhancing the dialogue among members of the medical and scientific communities about basic and clinical research efforts that relate to pancreatic cancer; Heightening public awareness of pancreatic cancer diagnosis, treatment, and prevention and providing informational support for pancreatic cancer patients, their families, and friends.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/nyu-nda032613.php

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